Category Archives: Paleolithic Diet - Page 4

Two Art de Vany-Related Ideas

I mentioned Art de Vany’s new book on Saturday; today I came across a few blog posts relating to some of his more important ideas and thought I’d talk about them.

The Economic Analysis of Diet

Today I recorded an interview with Jimmy Moore, which should appear on his “Livin’ La Vida Low-Carb Show” sometime early next year.

One of the things we talked about was our “economic” approach to nutrition and diet – how analyzing nutrients the way economists analyze factors of production helps sort out the confusing, seemingly contradictory results found in the scientific literature.

Since any factor calorie that is overly abundant will look like a “bad factor calorie” and any factor calorie that is too scarce will look like a “good factor calorie,” it’s easy to explain why the same nutrient can appear as “good” or “bad” in different studies.

Today, Mark Sisson features a passage from Art’s book. He says this:

At some point I realized that a human being is just another economic system. Indeed, your body contains an entire economy. There is the allocation of assets according to a hierarchy of needs. There are competing interests that sometimes struggle over resources and other times cooperate for the common good. There are surpluses. There are shortages. Like economies–like the movie industry–your body is a complex, decentralized system poised between chaos and order.

We tend to think of biologists as rigorous “hard” scientists and of economists as mushier “soft” scientists, but actually in analyzing complex cooperative networks economists are decades ahead of biologists.

The analysis in many biology papers, if translated into an economics paper with factors of production substituted for the dietary nutrients, would be recognized immediately by most economists as primitive and fallacious. Economists have developed many analytical ideas that diet researchers could usefully copy. It’s no surprise that Art and I both found our economics backgrounds helpful in sorting through the diet literature.

Intermittency in Diet

If there is a single idea that I associate with Art, it’s the desirability of intermittency and randomness to explore the extremes of the body’s metabolic networks.

Art touches upon this in the passage at Mark’s site:

According to chaos theory, certain systems that seem to be random in fact are not–it’s just difficult for us to perceive, at the outset, all the subtle factors that set the course and determine the outcome….

Another scientific concept, the power law, also comes up often in my discussions of health and fitness. It is based on the Pareto principle, named for Italian economist Vilfredo Pareto. In essence, it describes the relationship between how common a factor is and how much influence it exerts. It says that the most unusual events will have the greatest impact. Pareto’s study determined that 80 percent of privately held land in Italy was owned by 20 percent of the population.

Similar power laws exist all around us.

There is a power law of exercise, too: Your least frequent, most extreme exertions will have the greatest influence on your fitness. The peak moments of a workout count far more than the amount of time you spend working out…. When a work-out becomes an unvarying, monotonous routine, it loses its effectiveness.

Art’s ideas suggest that it might be beneficial to explore dietary extremes, for instance in calorie intake. Sometimes we should fast, forcing our body to economize on nutrients; sometimes we should feast, giving our body a surplus of nutrients that it has to dispose of.

In our book we discuss the benefits of intermittent fasting – it promotes autophagy, which extends lifespan and protects us against bacteria and viruses – but we don’t discuss whether feasting has any merits.

While there has been no real scientific study of feasting (except in the context of every-other-day implementations of intermittent fasting), feasting has been a hot topic in the Paleo blogosphere lately:

Coincidentally, Chris Masterjohn today offers us a review of Tim Ferriss’s new book, The 4-Hour Body.

For weight loss, Ferriss recommends intermittent fasting and feasting:

His fat-loss regimen sticks to a five-rule “Slow-Carb Diet” six days a week, but on the seventh day he resteth. This is the day for “reverse Lent,” otherwise known as bingeing on whatever the heck you want. In fact, Ferriss considers overfeeding one day a week to be a critical component of his fat loss regimen because of its effects on metabolism-boosting hormones.

In this respect he seems to have come to conclusions similar to those of Ori Hofmekler of Warrior Diet fame, who advocates fasting in the day and overfeeding in the night, and Matt Stone, whose High-Everything Diet uses overfeeding as its very lifeblood.

Stone recently told Jimmy Moore that one of the issues he’s still trying to tweak with his diet is to get rid of the initial gain in weight. Tim Ferriss may have solved that problem with his version of overfeeding, as folks on his diet usually gain weight on overfeeding day but nevertheless experience a net loss of several pounds per week from the very beginning.

So add Ferris to the group of self-experimenters who find benefits from occasional feasting.

Chris also discusses protein restriction:

Ferriss notes that periodic fasting from protein induces a process called autophagy, wherein the cell cleans out its mishandled, degraded, and aggregated proteins that otherwise accumulate. This is consistent with my experience. I had developed a problem with small wart-like risings on my hands and fingers at one point. Complete fasting for two weeks helped somewhat, but going vegan for two weeks made them completely disappear. The problem has never come back, despite my regular sumptuous feasting on animal foods of all kinds.

Perhaps protein cycling provides an answer to the question I had raised in The Curious Case of Campbell’s Rats. Namely, is there an intermediate intake of protein that maximally protects against cancer, toxicity, and fatty liver under all conditions? Perhaps the answer is not an intermediate intake of protein, but a periodic cycling of protein intake.

We note in our book (and this blog post) that protein restriction, even if calories are not restricted at all, promotes autophagy and therefore intracellular immunity and longevity. So we’re happy to endorse protein restriction.

But high intake of protein, especially of ketogenic branched-chain amino acids like leucine, does promote muscle synthesis. So what is a bodybuilder or athlete, who seeks the greatest possible muscle growth, to do?  Is there an inevitable conflict between athleticism and longevity?

It’s possible that protein cycling – say, a week of protein restriction followed by a week of high-protein intake – might help resolve the dilemma, providing 80% of the longevity and health benefits of protein restriction and 80% of the muscle synthesis benefits of high-protein diets.

If so, Art de Vany would not be surprised.

For the Love of Tubers

Welcome, Food Renegades!

Kristen Michaelis of the outstanding Food Renegade blog asked me to contribute a guest post. I wrote a defense of the “Paleo” nature of “safe starches” like tubers, roots, and corms, called  “For the Love of Tubers”.  Check it out! Especially if you want to know why I’m posting a picture of a Pandanus tree nut:

Pandanus nut. Source:  Wikimedia commons.

“For the Love of Tubers” will serve as today’s food-and-health post; I’ll also do an administrative post tonight about the book.

If this is your first time here, welcome! We are excited right now because our book, Perfect Health Diet: Four Steps to Renewed Health, Youthful Vitality, and Long Life, is about to come out; the proof copy arrived today, and copies will be shipped to buyers within a week or two.

Our belief is that everyone should and can become a healthy centenarian. Diet and nutrition, with occasional aid from antibiotics, is the key to defeating disease and postponing aging. 

If you have a disease of any kind, look for it in the categories list. I welcome requests for post topics, and am happy to explore the causes and cures of chronic diseases. My wife and I spent years figuring out how to cure our own chronic diseases; now we hope to help others, and in the process help shift medical practice toward natural healing methods based on diet and nutrition.

Welcome and please make yourselves at home!

The Danger of Protein During Pregnancy

At PerfectHealthDiet.com we’re advocates of protein restriction. We recommend:

  • Avoiding all protein-containing plants, as plant proteins tend to be toxic;
  • Striving to eat fatty, not lean, meats and fish, in order to keep protein intake down and fat intake up.

Protein restriction helps protect against viral and bacterial infections by promoting autophagy, the process of intracellular protein scavenging, digestion, and recycling.  During autophagy, bacteria and viruses, as well as junk human proteins and damaged organelles, are digested.  Autophagy has been strongly linked to longevity [1] and is protective against many diseases.

Our advocacy of low protein intake separates us from many other Paleo bloggers.  Loren Cordain, the dean of the Paleo movement, has long advocated consumption of lean meats.  Although he has moderated his stance somewhat, the front page of his site still places lean meats first among his favored foods:

Learn how a diet based on lean meats

The Paleo Diet is a way of eating in the modern age that best mimics diets of our hunter-gatherer ancestors – combinations of lean meats

(The other major difference we have with Dr. Cordain is his exclusion of starchy foods from a “Paleo” diet, even though starchy tubers have been part of the ancestral human diet for 4 million years. But that is a story for another day.)

Those who have read the pre-publication draft of our book know that we place high store on human breast milk as an indicator of the optimal composition of the human diet.  Human breast milk provides only 7% of calories in the form of protein. (Carbs are about 38% and fats about 55%.) One can debate whether 7% is the right level of protein for adults; but, if the principle of natural selection is sound, it must be that infants need a low-protein diet.

Science bears this out.  As our book notes, diets containing 20% of calories as protein are highly toxic to infants. Pre-term infants fed 20% protein diets had more fever, lethargy, and poor feeding than infants fed 10% protein diets, and lower IQs at ages 3 and 6 years. [2] Even a slight increase in the protein content of formula, from 7% to 9%, significantly increased the likelihood that babies would be overweight by age 2. [3]

Given our skepticism toward high-protein diets, especially for babies, we were pleased to see Dr. Cordain in his most recent newsletter [The Paleo Diet Update v6, #20 – Protein Intake for Pregnant Women] acknowledge the dangers of high protein intake by pregnant mothers. Dr. Cordain advises a pregnant mother:

[Y]ou probably should increase your fat and carbohydrate consumption, and limit protein to about 20-25% of energy, as higher protein intakes than this may prove to be deleterious to mother and fetus for a variety of physiological reasons….

“Protein intakes above this [25% of total calories] threshold may affect pregnancy outcome through decreased mass at birth and increased perinatal morbidity and mortality.” [4]

The physiological basis for this aversion stems from a reduced rate of urea synthesis during pregnancy that is evident in early gestation [5] as well as increases in the stress hormone cortisol [6]. Hence, pregnant women should include more carbohydrate and fat (i.e. fattier meats) in their diets and limit dietary protein to no more than 20-25% of their total caloric intake.

What are the long-term effects of a high-protein diet during pregnancy on the offspring?  In long-term follow-up studies of the adult children of mothers who ate high protein diets while pregnant between 1948 and 1954, it was found that by age 40 offspring commonly had high levels of the stress hormone cortisol [6] and high blood pressure [7,8].  The effects of faulty maternal diets can be long-lasting.

At PerfectHealthDiet.com, we think 20% is still likely to be a bit more protein than is desirable. We would advise pregnant mothers to restrict protein to about 15% of calories and to strive to obtain 30% of calories as carbohydrates.  As long as adequate carbs are obtained, there is only a modest need for protein and as little as 10% of calories as protein may be sufficient.

Note that this advice is very close to the ratios of 30% carb, 15% protein, and 55% fat that we recommend to adults and children generally.  Pregnant women may benefit from slightly more starch and slightly less protein than others; but on the Perfect Health Diet, pregnancy should not require a significant change in eating habits.

[1] Jia K, Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy. 2007 Nov-Dec;3(6):597-9. http://pmid.us/17912023.

[2] Goldman HI et al. Clinical effects of two different levels of protein intake on low-birth-weight infants. J Pediatr. 1969 Jun;74(6):881-9. http://pmid.us/5781798. Goldman HI et al. Effects of early dietary protein intake on low-birth-weight infants: evaluation at 3 years of age. J Pediatr. 1971 Jan;78(1):126-9. http://pmid.us/5539071. Goldman HI et al. Late effects of early dietary protein intake on low-birth-weight infants. J Pediatr. 1974 Dec;85(6):764-9. http://pmid.us/4472449.

[3] Koletzko B et al; European Childhood Obesity Trial Study Group. Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr. 2009 Jun;89(6):1836-45. http://pmid.us/19386747.

[4] Speth JD. Protein selection and avoidance strategies of contemporary and ancestral foragers: unresolved issues. Philos Trans R Soc Lond B Biol Sci. 1991 Nov 29;334(1270):265-9; discussion 269-70. http://pmid.us/1685584.

[5] Kalhan SC. Protein metabolism in pregnancy. Am J Clin Nutr. 2000 May;71(5 Suppl):1249S-55S. http://pmid.us/10799398.

[6] Herrick K et al. Maternal consumption of a high-meat, low-carbohydrate diet in late pregnancy: relation to adult cortisol concentrations in the offspring. J Clin Endocrinol Metab. 2003 Aug;88(8):3554-60. http://pmid.us/12915635.

[7] Campbell DM et al. Diet in pregnancy and the offspring’s blood pressure 40 years later. Br J Obstet Gynaecol. 1996 Mar;103(3):273-80. http://pmid.us/8630314.

[8] Shiell AW et al. High-meat, low-carbohydrate diet in pregnancy: relation to adult blood pressure in the offspring. Hypertension. 2001 Dec 1;38(6):1282-8. http://pmid.us/11751704.

Eleven Steps for Overcoming Alzheimer’s and Other Chronic Infectious Diseases

If Alzheimer’s is due to bacterial infection, as I suggested yesterday (https://perfecthealthdiet.com/?p=126), then it can be treated by diet, supplements, and antibiotics.

Here are eleven steps that can help defeat chronic bacterial infections, including the infections that cause Alzheimer’s. (Note:  I will justify each of these eleven steps, and cite to the scientific literature, in follow-up posts.)

1. Normalization of Vitamin D Levels.

Vitamin D is needed for the transcription of anti-microbial peptides, such as the cathelicidin LL-37 and beta-defensin, which are essential for defense against intracellular bacteria and viruses. Vitamin D deficiency is a risk factor for every chronic infection, and chronic infections tend to increase in frequency with latitude and progress most rapidly during the winter when vitamin D levels are low.  In general, a serum 25-hydroxyvitamin D3 level of 40 ng/ml (100 nmol/L in SI units) is a good target. (Some people, such as Dr. John Cannell of the Vitamin D Council, believe there may be benefits to higher levels, but this is speculative.)

2. Restriction of Carb Intake to 400 Calories Per Day.

Eating a carb-rich diet is doubly bad:  it increases blood glucose levels and triggers insulin release, both of which promote bacterial infections.

Intracellular parasitic bacteria need glucose or its glycolytic products to obtain energy. Abundant cellular glucose, caused by high blood glucose levels, enable them to reproduce and generate immune-impairing proteins more prolifically.

Insulin represses immune defenses against parasitic bacteria, by blocking production of antimicrobial peptides.

To keep both blood glucose and insulin levels low, carbohydrate consumption should be restricted to about 400 calories per day – the amount in 0.3 pounds of cooked white rice, or 1.3 pounds of sweet potatoes.

3. Restriction of Protein.

Eating minimal protein helps in two ways: it deprives bacteria of amino acids necessary for growth, like tryptophan; and it promotes autophagy, the primary means by which cells kill intracellular pathogens.

Indeed, the body’s primary defense mechanism against C. pneumoniae is tryptophan deprivation. This is why people with chronic brain infections have symptoms of serotonin deprivation, including depression, anxiety, insomnia, fatigue, impaired ability to concentrate, and low self-confidence. It’s important not to relieve this by tryptophan or 5-HTP supplementation, both of which promote bacterial growth. If symptoms are intolerable, selective serotonin reuptake inhibitor (SSRI) antidepressants, like Prozac, Paxil, or Zoloft, might be able to provide symptomatic relief. (NB: We neither recommend nor disparage these drugs.)

4. Intermittent Fasting

Autophagy is the garbage collection and recycling process of human cells.  When resources are scarce, cells turn on recycling programs and send garbage collectors known as lysosomes to engulf and digest junk proteins and damaged organelles, enabling re-use of their amino and fatty acids.

Autophagy is a key part of the immune defense against parasitic bacteria.  Lysosomes not only digest human junk, they seek out bacteria and digest them. 

Autophagy is strongly turned after about 16 hours of fasting. The longer one fasts, the more parasitic bacteria are destroyed in lysosomes.  Fasting is an easy way to improve the relative balance of power between your body and intracellular pathogens. Fasting strongly promotes autophagy in neurons, and is of therapeutic value for Alzheimer’s.

A simple strategy of intermittent fasting is to confine meals to an 8-hour window each day, thus engaging in a daily 16 hour fast.  On this strategy, one might eat only between noon and 8 pm.

5. Ketogenic Fasting.

Two dangers of fasting are that it can lead to loss of muscle tissue as protein is consumed to generate ketones and glucose, and that neurons may be put under stress by glucose deprivation.

Both dangers can be ameliorated by eating ketogenic fats during the fast.  “Ketogenic” means generative of ketone bodies. Ketone bodies, which are generated from fats or some proteins during fasting, are the only neuronal energy source that bacteria can’t steal. There is a large literature showing that high circulating ketone levels are neuroprotective, and ketogenic diets have been successfully tested as Alzheimer’s therapies.

The most ketogenic fats are the short- and medium-chain fats found abundantly in coconut oil. Taking plentiful fat calories from coconut oil, but no carb or protein calories and few other fats, can enable fasts to be extended substantially longer with minimal loss of muscle tissue or neuronal stress.

On a ketogenic fast, eliminate carbs and protein for a 36-hour period, from dinner one day to breakfast on the second day.  During the intervening day, eat no protein or carbs, but do eat as much coconut oil as you like.

There is no limit on how much coconut oil may be consumed – but 12 tablespoons per day would produce a surfeit of ketones. NB: Always drink plenty of water during a fast. We also drink coffee with plentiful heavy cream.

6. Elimination of Wheat and Other Grains. 

Wheat is a toxic food that interferes with immune defenses and impairs vitamin D function. It also generates antibodies to the thyroid, which damage the thyroid status and further impair immune function.

7. Elimination of Omega-6-Rich Oils and Inclusion of Omega-3-Rich Fish.

A diet that minimizes omega-6 content by replacing soybean oil, corn oil, canola oil, and other omega-6 rich oils with butter, coconut oil, and beef tallow, and gets adequate omega-3 fats by eating salmon or other cold-water fish, optimizes the immune defense against intracellular pathogens.

A high omega-6 and low omega-3 diet weakens immune defenses against intracellular pathogens and re-directs the immune system toward extracellular threats.

Note that the combination of carbohydrate, protein, and omega-6 fat restriction necessarily means that half or more of calories should be obtained from saturated and monounsaturated fats.  It is important not to have a saturated fat phobia if you want to escape or defeat Alzheimer’s!

8. Fructose Minimization.

Fructose is a toxin and is deprecated on the Perfect Health Diet. One of its worst features is that promotes infections. In mice, blood levels of endotoxin, a bacterial waste product, are higher on a fructose-rich diet than on any other diet.

Therefore, sugary foods like soft drinks should be eliminated.  Fruit and berries are OK in moderation.  We recommend no more than 2 portions of fruit and berries per day. Most carb calories should be obtained from starchy foods, like sweet potatoes or taro or white rice.

9. Melatonin supplementation. 

Whereas vitamin D is the “daylight hormone,” melatonin is the “hormone of darkness.”  It is generated during sleep, and is favored by darkness.  Even a little bit of light at night, like the LEDs of an alarm clock or streetlights shining through a window, can disrupt melatonin production.

Melatonin is extremely important, not least because it has powerful antibiotic effects.

To maximize melatonin production, everyone should sleep in a totally darkened room, with windows covered by opaque drapes and all lights extinguished and LCD or LED clocks turned face down.

Unfortunately, people with chronic bacterial infections will generally still be melatonin-deficient, for the same reason they are serotonin-deficient:  melatonin is derived from tryptophan and serotonin. Fortunately, melatonin is easily supplemented.

A melatonin tablet can be allowed to dissolve in the mouth just before bed. High doses will generally produce a deep sleep followed by early waking; this can be remedied by using time-release capsules, or by reducing the dose.

10. Selenium and Iodine Supplementation and Thyroid Normalization.

This is basic for good health in all contexts, but optimizing thyroid hormone levels and maintaining iodine and selenium status are especially important for anyone with an infection.

Both selenium and iodine are required for proper immune function. To get iodine, white blood cells will strip iodine from thyroid hormone; for this reason, people with chronic infections are often somewhat hypothyroid, as indicated by TSH levels above 1.5.

There are too many tricks and pitfalls to thyroid normalization to describe the whole issue here, but a good start is to eliminate wheat from the diet, and to obtain 200 mcg selenium and at least 400 mcg iodine per day. Do not get too much selenium as it is toxic.  Selenium and iodine may be obtained from foods:  two to three Brazil nuts a day for selenium, and seaweed for iodine.

11. Vitamin C and Glutathione or NAC Supplementation.

These are important for immune function. Vitamin C supplementation is an important safety precaution because infections greatly increase the rate of loss of vitamin C, and can generate tissue scurvy with devastating consequences.

Glutathione is destroyed by stomach acid. We recommend buying reduced glutathione and taking it with a full glass of water on an empty stomach, at least 2 hours after and 1 hour before taking food. Alternatively, N-acetylcysteine (NAC) and glycine-rich foods like gelatin may be taken to promote glutathione synthesis.

Conclusion

This is by no means an exhaustive list of dietary and nutritional steps that can help against chronic infections.  However, we believe these are the most powerful and important steps.

Alzheimer’s and other diseases caused by chronic bacterial infections – possibly including multiple sclerosis, Lyme disease, chronic fatigue syndromes, fibromyalgia, rheumatoid arthritis, and many others – are preventable, treatable, and often curable.  These dietary steps, along with appropriate antibiotic therapy, are keys to a cure.