Supplements

This page lists our supplement recommendations with links to products at Amazon. By purchasing via links on this page, you support the blog at no cost to yourself. Thank you for supporting our work!

Supplemental Foods

We recommend eating these “supplemental foods” on a regular schedule:

  • 3 egg yolks daily, 5 yolks daily for women who are pregnant or planning to become pregnant (for choline, folate, vitamin A)
  • A bowl of soup made from bone, joint, tendon, foot, or hoof stock, 3 days per week (for calcium, phosphorus, and collagen)
  • Fermented vegetables such as kimchi, sauerkraut, or fermented mixed vegetables (for nucleotides, probiotic bacteria, and vitamins K2 and B12), and other vegetables such as tomato, avocado, potato, sweet potato, banana, green leafy vegetables, and seaweeds such as dulse, daily (for potassium)
  • ¼ lb beef or lamb liver, weekly (copper, vitamin A, folate, choline). If you like, substitute ¼ lb chicken, duck, or goose liver weekly plus 30 g 85% dark chocolate daily
  • fish, shellfish, eggs, and kidneys, weekly (for selenium)

Daily Supplements

These are supplements we recommend be taken daily:

  • Sunshine and vitamin D3 as needed to achieve serum 25OHD of 40 ng/ml.
  • Vitamin K2 100 mcg or more
  • Magnesium 200 mg
  • Iodine 225 mcg
  • Vitamin C 1 g
  • Pantothenic acid (vitamin B-5) 500 mg
Vitamin D3
  • Seek total dose from sun, food, and supplements of 4,000 IU/day
  • Adjust to 25OHD level of 40 ng/ml (whites/Asians), 30 ng/ml (blacks)
Vitamin K2
  • Recommended dose: 100 mcg MK-7
  • Pharmacological, possibly therapeutic doses: 1000 mcg to 5 mg MK-4
Magnesium
  • Use chelate (e.g. glycinate) or citrate
  • Daily dose 200 mg
Iodine
  • Recommended dose 225 mcg/day (one tablet)
  • Nori sheets have about 50 mcg each; 2-4 per day replaces supplements
  • Supplementation is to prevent lengthy iodine droughts
Vitamin C
  • Low dose: 500 mg – 1 g per day
  • Under stress or viral infections, more may be needed
  • Powder is least expensive way to get large doses
Vitamin B-5 (pantothenic acid or pantethine)
  • 500 mg per day; we suggest daily due to its extreme safety
  • Acne/skin blemishes or low energy/endurance are symptoms of deficiency

Weekly Supplements

These are supplements we recommend be taken once a week:

  • B vitamins:
    • 50 to 100 mg each of B1, B2, and B6
    • 5 mg biotin
    • 500 mcg B12
  • Zinc 50 to 100 mg
  • Boron 3 mg
B1 (thiamin)
  • 50-100 mg weekly
B2 (riboflavin)
  • 100 mg per week
B6
  • For those who don’t take a B-50 complex
  • We recommend 50 mg to 100 mg per week
Biotin
  • We recommend 5 mg once per week
B12
  • We recommend 500 mcg to 1 mg once per week
  • Sublingual methylcobalamin is preferred
Zinc
  • We recommend about 50 mg per week
  • Be sure to follow our copper recommendations as copper-zinc balance is crucial
Boron
  • The 3 mg dose can be taken one to three times per week

Prenatal Supplements

The most important prenatal supplements are:

  • Extra duck, goose, or pastured chicken liver.
  • Extra egg yolks.

The following supplements may also be helpful during pregnancy or in the months leading up to conception. Note: We do not recommend prenatal multivitamins.

Choline
  • Not necessary if you eat enough egg yolks and liver
  • But extremely important during pregnancy, and safe
Inositol plus Choline
  • Not necessary if you eat enough egg yolks and liver
  • If supplementing choline, good to mix in some inositol
Iron (optional)
  • About 30% of pregnant women develop iron deficiency anemia
  • Don’t guess, test; blood tests will indicate if you need iron supplements

Optional Supplements


These supplements may be helpful for a significant fraction of the population. Experiment to see if they help you:

  • Probiotics
  • Chromium, 200-400 mcg per week (not necessary if you cook in stainless steel pots) and (optional) vanadium, 25 mcg per week
  • Lithium 5 to 10 mg per week
  • Silicon 5 mg to 25 mg daily
  • FOR PEOPLE WHO DO NOT EAT LIVER: Copper 2 mg per day
  • FOR PEOPLE WHO DO NOT EAT LIVER: Vitamin A from cod liver oil, 50,000 IU/week
  • FOR PEOPLE WHO DO NOT EAT MAKE BONE STOCK OR DRINK MINERAL WATER: Calcium up to 400 mg/day
  • B-50 complex (as a substitute for individual B supplements if you prefer fewer pills
  • Molybdenum 150 mcg per week
  • Taurine 500 mg to 5000 mg per week (higher doses may be therapeutic for small intestinal or systemic infections)
  • Selenium 0 or 200 mcg per week depending on selenium content of food (if food is produced in dry, flat areas = high selenium, no supplements; rainy, well-drained areas = 200 mcg/wk)
Probiotics
  • Bifidobacterium spp can help with leanness and weight loss.
  • Lactobacillus spp can help with acid reflux, bloating, SIBO, prediabetes, high triglycerides
More Probiotics
  • Bifidobacterium spp can help with leanness and weight loss.
  • Lactobacillus spp can help with small intestinal issues
More Probiotics
  • VSL#3 is a good mix for inflammatory bowel diseases.
  • Prescript Assist includes soil-based organisms that are a little riskier and should be taken only occasionally, not continuously, for therapeutic reasons.
Chromium
  • If you don’t cook in stainless steel, we recommend 200 mcg chromium one to three times per week
  • Stainless steel pots may release 88 mcg chromium per day of use
  • Optional: vanadium 25 mcg one to two times per week
Lithium
  • Best is to take 1 mg per day; 5 mg once or twice per week is next best
  • Caution: too much lithium can exacerbate hypothyroidism and increase potassium excretion
Silicon
  • Up to 25 mg per day
  • Most people would benefit from more silicon
  • Seaweed is a good food source
Copper (Only If Liver Is Not Eaten)
  • Target of 2-3 mg/day can be met by eating 1/4 lb beef or lamb liver per week
  • Do not supplement copper if you eat liver
Vitamin A (Only If Liver Is Not Eaten)
  • Target of 50,000 IU/week with remaining A needs met from carotenoids (green leafy vegetables and orange plants like carrots)
  • Do not supplement vitamin A if you eat liver, unless for therapeutic reasons
Calcium (If No Mineral Water or Bone Stock)
  • PHD foods may fall short of calcium target by up to 400 mg/day
  • Standard PHD prescription is to make up the difference with bone stock and/or mineral water
  • These supplements also replace magnesium supplement; aim for 300-500 mg calcium and 150-250 mg magnesium per day
B-50 complex
  • An alternative to the other B vitamins for those who prefer to take fewer pills
  • Not recommended more than once per week due to folic acid and niacin content
Molybdenum
  • We recommend 150 mcg to 1 mg per week
Taurine
  • We recommend 500 to 1000 mg weekly for healthy persons
  • Supports production of bile salts
Vitamin E
  • Red palm oil is a good food source
  • If supplementing, take mixed tocopherols and tocotrienols

Therapeutic Supplements

These supplements are unnecessary for healthy people but may be helpful in various disease conditions.

N-acetylcysteine
  • Precursor to glutathione
  • Recommended dose is 500 mg
  • Can take more in cases of severe chronic infection
Glycine
  • Supports collagen production, bile conjugation, and glutathione production
  • Desirable if you don’t eat daily extracellular matrix (bones, joints, tendons, skin, hooves)
  • Up to 2 teaspoons (10 g) per day
Creatine
  • Supports muscle growth and preservation; especially valuable for the elderly
  • Up to 1 teaspoon (5 g) per day
Melatonin
  • An important sleep hormone, deficient in many brain diseases, has antimicrobial activity
  • Take 1 mg sublingually just before bedtime
  • For larger doses, combine 5 mg time-release with 1 mg sublingual
Detoxification Aids
  • These can help bind toxins and excrete them in feces, preventing them from being re-absorbed in the colon
  • Likely to be helpful for most people suffering from chronic infection or environmental mold.

Miscellaneous


These items may be helpful in implementing Perfect Health Diet and Lifestyle advice.

Pill boxes
  • Set out pills once per week, aids remembering to take them
Pill cutter
  • For cutting tablets to reduce the dose

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Leave a comment ?

4,434 Comments.

  1. Hi Paul and gang!
    does anyone know – Is there any multivitamin(s) that covers most or even some of the recommendations so as to not have to take SO many different pills?

    Thanks!

  2. To identify these potential savings, Frost & Sullivan conducted a systematic review of hundreds of scientific studies on eight dietary supplement regimens across four diseases to determine the reduction in disease risk from these preventive practices. The firm then projected the rates of medical events across the high-risk populations and applied cost benefit analyses to determine the cost savings if people at high risk took supplements at preventive intake levels.

    http://www.crnusa.org/CRNfoundation/HCCS/index.html

  3. Any recommendations for a probiotic? I’m having a hard time with cruciferous veggies. THX!

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  5. Any thoughts on the following supplemental foods:
    (1) Brewer’s Yeast for B vitamins (except B-12), selenium, chromium?
    (2) High-vitamin C berry powders for natural vitamin C?
    (3) Egg shell broth for matrix nutrients?
    (4) Azomite mineral powder or nutritional clays for minerals and silicon?

    • Hi Euthyphro,

      (1) It’s OK in small amounts but can be inflammatory (including fungal cell wall components) and has a somewhat peculiar mix of micronutrients, eg it is high in chromium, so if you want larger doses of supplements I would go elsewhere.

      (2) Again, fine for low doses but for higher doses in illness I would look for pure ascorbate as a safer option.

      (3) No. We recommend bones for calcium and you can easily get too much calcium, so I don’t see any need for eggshells. Extra matrix is best obtained from joint material or tendons.

      (4) I would consider these therapeutic supplements, for eg parasitic gut infections, rather than a routine food item. You can easily get too much of some things. They are nutritious in small amounts.

      • Thank you very much for the sound advice. I see the argument for some supplements, but I seem to do better when the supplements are natural. (E.g. Fermented cod liver oil, epsom salts, K2 from natto)

        When I take ascorbic acid, it seems to produce side effects, including dandruff, so I’ll just stick with red bell peppers for vitamin C. A single red bell pepper in conjunction with a balanced diet would seem to supply an abundance of vitamin C.

        So far, the Brewer’s yeast seems to be helpful in moderate-low doses.

        I read somewhere that the inner membrane of the eggshell contains glucosamine, which is why I was curious. Thanks again!

  6. As a natural sweetener, I was wondering what you might think of Blue Agave Nectar: lower on Glycemic Index [Gl17] and only about 60 calories per Tablespoon.

    • Hi Kathy,

      As Donna says, agave is not recommended because it is so high in fructose. We recommend dextrose powder as a dry sweetener and honey as the safest syrup.

      • Isn’t honey reasonably high in fructose? also wouldn’t rice/tapioca syrup be a better syrup? thanks Paul

        • Yes but that’s OK if the quantity is small, which it probably is. We used to recommend rice syrup but the arsenic scares got us to switch over. Genuine honey seems to have a good effect on gut flora. Tapioca syrup is good.

  7. I think agave has quite a bit of fructose in it which is not advised in the PHD book. Corn syrup (not the high fructose one) is dextrose (I don’t think there is any fructose in it) although not low glycemic. I have been using Stevia, Xylitol and Just Like Sugar (all low glycemic). And I am about to try a Vitacost product (a powder)which is stevia combined with inulin.

  8. Is dextrose ok for diabetics? Do you have objections to stevia, xylitol and Just Like Sugar? if so, could you explain why? Thanks Paul, Donna

  9. I’ve been using xylitol which was recommended to me by others. I’m concerned about dextrose which is a corn product – I’m sensitive to corn and I avoid all of its derivatives. There seems to be a lot of conflicting information on the net about xylitol – some feel it’s very safe, others not so much. What’s the deal? It can upset stomachs, but I haven’t had that problem.

    Thanks!

  10. Xylitol doesn’t bother me either. For those people who are bothered by it, erythritol does not have the GI side effects. I worry about corn also, expecially GMO corn. Also, I have a mold allergy and evidently corn contains mold.

  11. Is the arsenic concentrated in the bran? because you already eat a lot of white rice so wouldn’t that contain arsenic?

  12. Hi Paul,
    I’ve only just discovered your site and I’m still waiting for your book from Amazon. I’m the new kid on the block here, so I apologize for the basic question. I’ve been taking krill oil for years and now I’m being recommended to take cod liver oil. I’m getting the impression you don’t think it’s necessary if you eat oily fish. Can you explain to me why CLO it’s potentially harmful, I’m a little behind on this whole debate.
    thank you
    Jane

    • Hi Jane,

      We recommend getting only specific amounts of omega-3 fats and vitamin A. Our liver prescription provides a reasonable amount of A and salmon once a week provides omega-3s in a form that is probably fresher than any cod liver oil, since the oil is processed and can be quite old.

      • Hi Paul,
        Just received your book and can’t put it down! 🙂 I’m coming off being vegan for 6 yrs and I only eat egg yolks, goats cheese, fish. I don’t want to eat liver, so I guess I’ll have to supplement to get vit A. What do you think of getting extra omega 3 from marine phytoplankton supps?

  13. Which brand? from what I understand pretty much every brand whether grown in Pakistan or California or the southern states contains arsenic.. just in varying levels.

  14. Hey Paul,

    Any thoughts on this recent Dr Mercola article regarding copper?

    http://articles.mercola.com/sites/articles/archive/2013/09/12/copper-alzheimers-disease.aspx

    He is recommending 50-100 micrograms/day. Is there new info out there?

    Thanks.

    • Hi David,

      Although the amounts given to mice in that study may seem small, they are really quite large: 130 mcg/L to mice who drink 6 mL per day means about 1 mcg/day, which in a 20 g mouse is the same as 40 mg copper per day in an 80 kg human. Our PHD copper range is 2 to 4 mg/day. (See http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397713/ for info on mouse weights and drinking quantities.)

      Also, copper needs to be balanced with zinc which we recommend supplementing, the mice were not given zinc.

      Overall, I am not aware of new information out there about copper toxicity. There is a concern about copper from pipes or cookware leaching into acidic water. But assuming drinking water has low copper levels, our dietary recommendations should be fine. Note we don’t recommend supplementing copper, rather getting it from liver.

      • Thanks for the reply. I definitely need to do better in regards to eating liver weekly. I have been using the copper supplement as a crutch.

        David

  15. Hello Paul,

    I have posted questions in the past regarding low iodine. I did a spot and 24 hour urine test and have low-very low levels. After reading your post on iodine I want to make sure that I don’t forget the selenium, however, when I eat brazil nuts (1-2) I get very bad headaches (I’ve tested this two or three times myself so not all that scientific). I have read too much selenium can cause headaches.

    (1) Should I try to get selenium another way or do you think the headaches indicate that I don’t need more selenium? I also have histamine issues which is why I’m limited to the foods I can use.

    (2) I have read getting iodine levels back up can help shrink cysts etc. Have you come across this in your research?

    Thank you for any help you can give.

    • Hi Amy,

      I don’t believe acute headaches will be due to selenium, rather due to some sort of allergic/immune reaction to something in the nuts. It could be amine-related (histamine, tyramine) or it could be mold as MB says. Yes, get selenium another way.

      Yes, increased iodine can cure or improve fibrocystic breast disease. In general it’s a good thing to take a daily supplement of iodine – 225 mcg/day is a good dose.

      Best, Paul

  16. Just a thought.. brazil nuts are known to contain a lot of mold. You may be allergic to this mold. I would try a selenium supplement.

  17. First of all I want to thank you for one of the best blogs I ve ever read. I have a question, you said that you dont recomand multivitamin in pregnancy, why?

  18. Dear Paul:
    I believe you don’t recommend daily consumption of bone broth…
    Why is that???
    And what is the best regimen for consuming chicken bone broth???
    Thanks so much…
    Linda

  19. Thanks so much for answering my question, Paul…
    Such important information for me and others.
    The bone broth idea is being hailed as such a panacea and something
    that can be imbibed all day long, as a beverage.
    I remembered that you had said not to drink it too frequently, but couldn’t remember exactly how much.
    I’ve loaned out my book so I couldn’t check the information there.
    I so appreciate it…
    Linda

  20. Hi Paul, How many mg of calcium are there per cup / bowl of bone broth? I had read it was a very small amount?

  21. Paul,
    I am about to start following the supplement recommendations. What is your opinion re. taking other supplements such as: resveratrol, turmeric, green tea, alpha lipoic acid, CoQ10, DHEA, probiotics, etc. It would be a real change for me if I reduced my vitamin-mineral supplement usage and dropped these other supposedly healthful supplements. Also, do you have recommendations re. when to take supplements (with meals, before or after, empty stomach, with fat, etc.).

  22. Paul,

    My wife and I seem to suffer from upset stomach / nausea when we supplement with selenium. Is that a normal side effect, or an indication of some other issue?

    Note, we follow your recommendations of 200mcg weekly, since we do not eat a full pound of ruminant meat / seafood daily. Though, our meat does come from farms in Iowa and Wisconsin, perhaps we get enough Se already.

    Thanks,
    -Kenny

  23. Hi has anyone heard of or tried Protandim? It is an anti oxidative supplement that has been backed up by 15 Pub med studies.

    • 🙄 Daniel this is another multi-level marketing company out to make money! don’t fall for it. The ingredients are: Ashwaganda, green tea extract, turmeric, milk thistle and bacopa. All of these can be purchased for a fraction of the price from your local health food store. They are excellent for detoxification and liver cleansing. Also don’t be impressed by PubMed studies, take a closer look at them and check the sample size and results very carefully. Citing studies is just another marketing technique the MLM companies like use to impress people. I fell for MaxOne years ago! Never again.

  24. Hi Paul,

    I recently read an article from Natural News on Liposomal Vitamin C and Liposomal Glutathione. I was about to replace my NAC, but was wondering if I should go for the Liposomal Glutathione. I saw some related articles about Glutathione levels and Vitiligo (which I have). And the need for this type of Vit. C for eye health and overall general wellness. I was just wondering your thoughts on this? Art Devany has been a huge fan of Glutathione and I recently read something about it on Chris Kresser’s site. It’s pretty expensive though. Thank you Paul!

    Janis

  25. Oh and one more thing….I’ve been taking MK7, but have a growing concern about it being derived from soy (natto). My mother is allergic to soy (and everything else!) and I seem to be following in her footsteps. Should I be concerned about this as being an allergen and soy having estrogen like properties? I read your book awhile ago, and I do apologize if this issue has already been addressed. Thank you for the taking the time!

    Janis

    • Hi Janis,

      The soy allergens are proteins and I believe the MK-7 tablets are protein free. So I wouldn’t worry. I suppose you could do an experiment — don’t take them for a week, then take maybe 10 on one day, and see if you notice anything like a reaction.

      • Thank you Paul for your response. That’s good to know. Any thoughts on the Liposomal Glutathione and Vit. C? (the comment prior to the MK7) Or should I just stick with NAC? Or anything at all? As far as I can remember, I believe you don’t recommend Glutathione. Just want to pick your brain! Thanks Paul!

  26. Paul,

    I am your avid fan and follow your blog as well your recommended diet and supplements as per your Book – Perfect Health Diet. I have read number of books on Health,Nutrition and can confidently mention PHD is “the best” –it is all encompassing with necessary scientific support. I feel that it should be talked about book in all school and colleges as go to book on Nutrition. Thank you for writing the book and sharing your knowledge and experience with the world.

    I have question on Manganese –what is your recommended range ( Book does not specifically give range ) however you have highlighted toxicity issues very well.

  27. Hi Paul,

    I see that you have mentioned you are no longer recommending rice syrup because of the possible high arsenic content.

    I am wondering what your thoughts are regarding white rice vinegar and arsenic vs brown rice vinegar and arsenic and whether we should avoid it entirely.

    Erich

  28. I can’t quite figure this out: In your book on pgs 265-6 you say that “Vit K comes in plant form K1 and in animal and bacterial forms called K2” and then say “that the main forms of K2 are MK-4 which the liver manufactures from dietary K1….” So, it would appear that K2 is present in plant forms too since the liver is manufacturing it from K1 which are the plant forms.
    Thanks

    • hi Sean,

      those quotes are not saying that K2 exists in plants, it is basically saying that the human body can make K2 from the K1 in the plants we eat.
      ie.
      the body can make K2 MK4 in the liver (from K1).
      & our gut bacteria can make K2 MK7 (from K1).

      This is what wiki has to say on K2 MK7,
      “Bacteria in the colon (large intestine) can also convert K1 into vitamin K2.
      In addition, bacteria typically lengthen the isopreneoid side chain of vitamin K2 to produce a range of vitamin K2 forms, most notably the MK-7 to MK-11 homologues of vitamin K2.
      All forms of K2 other than MK-4 can only be produced by bacteria…”
      http://en.wikipedia.org/wiki/Vitamin_K

    • with K2 MK4, just reading some wiki’s, which basically say that,
      K2 MK4 can be made by the human body by converting K1 (ie. the K1 in plants),
      but it does not say that this conversion happens in the liver.
      That said, animal liver is a good source of K2 Mk4, so i assume K2 Mk4 exists in the human liver as well (may be just not made there?).

      some text from another wiki:
      “MK4 is produced via conversion of vitamin K1 in the body, in the testes, pancreas and arterial walls”
      http://en.wikipedia.org/wiki/Menatetrenone

  29. Hi Paul,
    Have you come across vitamin b complex recommendations for adrenal fatigue in your research? Any recommendations you could make for breastfeeding women with adrenal fatigue (supplements etc) would be much appreciated. i’ve been taking 3 B complex daily which includes 1000 mcg folic acid/day.
    thanks

  30. Hi Paul I have read that Melatonin has many negative health effects… How can you supplement it confidently with these controversies?!
    *I have difficulty sleeping*
    Thankyou so much for your time 🙂

  31. I would sure appreciate some help: I’m about 7 weeks pregnant (first pregnancy). I know that you recommend individual supplements and not a prenatal, but I’m confused about liver/fish. At this point, fish and most meat is utterly repellant to me. I can’t even stand the smell. In fact, my husband made baked smelt last night (his favorite) and I almost had to leave the house I was so nauseated.

    The recommendations for fish oil/DHA is EVERYWHERE. If I can’t eat fish right now, should I supplement? If I do, where do I find a high quality supplement.

    Thanks in advance for any help!

    • I recommend Barlean’s Organic Omega Oils. They don’t have a fishy taste and are really good for you. Supposedly they have tested them for absorption and they absorb a lot better than regular fish oil and the fish oil has been purified to remove heavy metals, which is super important. I personally like the pina colada flavoured one. I tried them because fish oils pills gave me a horrible aftertaste of fish and although not pregnant, I have a revulsion towards that smell and taste.

  32. Hi Paul,

    Thanks for your informative website! I was wondering if there is any supplement you would recommend for hair loss in peri menopausal women. I have been taking b complex with biotin, vitamin d3, cq10, and cod liver oil with no results. Any inputs would be greatly appreciated!
    Thanks in advance!
    Sarah

  33. Try Biosil (which has biotin in it too)a Lorna Vanderhaeghe supplement – or the less expensive Jarrosil (by Jarrow – does not have biotin). It helps bone density but is now also marketed for hair, skin and nails.

  34. The Dangerous Durbin Anti-Supplement Bill

    http://www.anh-usa.org/durbin-anti-supplement-bill/

  35. Paul,
    Would you recommend potassium supplementation, and if so how much, for someone who’s unable to tolerate fruits and vegetables?

    Also, are you (or anyone else) aware of any transdermal delivery methods for ascorbic acid in cases where vitamin C orally is not tolerated?

    Thanks!!

  36. Hello Paul!

    What type of supplementation would you recommend for a vegan eating about 1-2 servings of soy products per day, mainly tofu and tempeh, and properly prepared legumes? I know these foods are not PHD approved but I am not a vegan for health reasons primarily, although I do feel better without meat in my diet.

    • Hi Markus,

      You would really have to look at the peak health ranges in our book, estimate your intake from diet — maybe take a food log for a few days and look things up on nutritiondata.com and calculate nutrient intakes in Excel — and subtract the two to assess what you should supplement.

      I’ve thought about how to supplement on PHD, but on other diets, you need to look at what you are getting from food and see what’s missing.

  37. Hi Paul,
    I wonder if you have any insights into this health mystery? I have your latest book and adhere closely:
    Yes: eggs, beef, healthy fats, safe starches, veg
    No: sugar, veg oil, grain (except rice)
    Good sleep, low stress, lift weights, cycle 100 km/week.
    Age 40 with recent personal bests on exercises, brain is very clear, 25-OH 60, CRP 0.1.
    However, I am experiencing wasting and dry scalp, BMI 17.5 and dropping, some skin elasticity loss.
    Markers that are high are: TSH 2.3, HDL 103, LDL 192, TG 57. IGG and IGA are in upper range also.
    Any ideas on what to look for?

    Thanks,
    Kevin

    • Hi Kevin,

      I’m guessing you might be low in vitamin A and maybe vitamin C. Do you eat liver once a week? Also eat plenty of carotenoid rich plants like sweet potatoes, carrots, spinach, and persimmons. I would try flavoring water with ascorbic acid powder for C.

      You might be oversupplementing D since 25OHD is high. Be sure to supplement some iodine and zinc.

      Finally, it looks like you may be subclinically hypothyroid. You could ask your doctor for a low dose of T4 thyroid hormone and test whether it makes you feel better. You could also ask for a test of T3 and T4 levels.

      • Hello Paul,

        Is TSH of 2.3 subclinically hypothyroid? My test recently came in at TSH 2.6, FT4 0.9, FT3 2.2. Doc said this was normal. Should I be viewing this as problematic and possibly linked to my high LDL (199)?

        I do take potassium with iodine and eat a lot of seaweed.

        • Yes and yes.

          Try working on gut health with vitamin A, D, C, zinc, collagen.

          • Thank you, Paul! I think I get enough A and I supplement 3000 IU of D and 1000mg of C daily. Should I take zinc daily, too? And can you recommend a way to supplement collagen?

          • Zinc – get 100 mg/week. Collagen – you have to cook, joints, tendons, bones, tripe. Simmer them for multiple hours.

          • I’ve read that LDL / cholesterol elevations can be one of the body’s way to fight infection – comments, Paul? If so, would thyroid meds to reduce TSH/LDL impede this process?

          • Hi Donna,

            LDL does serve an immune function, but most people who have high LDL become overly inflamed. If the mechanism behind high LDL was hypothyroidism, then the high LDL will be generating too much inflammation and it will be good to take the hormone.

      • Hi Paul,

        Thanks for the rapid suggestions. I feel great but weight loss is becoming concerning. I’ll try A, C, I, Z and reducing D. Good point on the thyroid; TSH was higher previously (felt awful) but would prefer under 1.

        Kevin

  38. I just saw something on Livestrong which says that we’re wasting our money if we use digestive enzyme supplements because they’re destroyed in our stomachs. Is that true?

    Judy

    • Hi Judy,

      I don’t think they’re necessarily destroyed in the stomach, especially if taken between meals, but they rarely provide benefits.

    • Go to Mercola.com, search digestive enzymes and read the 1st two articles. A lot of detail about digestive and other enzymes and how to promote digestive enzymes. I take his product (Digestive Enzymes) and they help me alot.

  39. Hi Paul
    I’ve been drinking those fermented cocobiotic drinks for years, believing that I’m getting living bacteria into my gut. Someone told me recently that the bacteria dies once it’s eaten all the food source in the bottle which is usually honey & grains. Do you think this is true? and that the sediment in the bottle is dead bacteria and waste?.

    • there could be some merit to that.

      you know how some probiotic supps need to be refrigerated, the theory behind that, is that this puts the bacteria in to a dormant state, which means they stop feeding off the ‘food’ included in the capsule.
      then when you pop the capsule it warms up in your body & the bacteria ‘wakes up’.

      so if this is the case, handling is important, if the bacteria is non-dormant (from non refrigeration) for too long, they will run out of food & die…which may or may not be the case for your cocobiotic drinks?

      then there is the shelf stable probiotics, which someone told me once were dead bacteria…but that makes no sense to me?

      • thanks for those thoughts. Yes, the probiotic drink can be at room temp on the shelf for months before I open it. The lacto bacteria and food source are self pressurized in the bottle. So based on what you say, most likely they are dead, otherwise there would be uneaten grains in the bottle, when there is actually fine sediment. So I’m drinking dead bacteria and their poo? 😳

  40. Hey Everyone i just found out about this product called RDA-12. Basically it is a product that helps you achieve your micro nutrient requirement. Each serving has 6 servings of your fruit and vegetable requirements. Which equates to 50% of your daily requirement. The product uses no synthetic vitamins or fillers. So if you want 100% of your daily RDA for fruits and vegetables then you take two doses spread out throughout the day.
    for more information take a look at.
    http://www.rda-12.com

  41. Hi Paul, just wondered what your take on taking Gt Lakes gelatin as an extra supplement is?
    I presume that I got where I am
    (Rheumatoid Arthritis) by creating intestinal permeability. I do make bone broth but really want to heal any permeability.
    It is advised to take just before bed and first thing in the morning. With it being protein, should I try and fit within my 8hour eating time? I really want to starve the negative bacteria as almost certainly causal
    Thanks so much, and thank you for helping so many people

    • Hi Lynne,

      We recommend cooking soups and stews with bones, joints, and tendons — that will give a better range of nutrients than any commercial gelatin.

      The timing issue is a good question. I do think it’s best to take it within the feeding window.

  42. Hi Paul:

    I noticed you don’t include Ubiquinol in your supplement recommendations. Why? Should everyone over age 25 take at least 100-200 mg/d? Your thoughts and insight would be helpful.

    • Hi Eddie,

      The jury remains out on this one, but I think zinc and copper provide the best extracellular antioxidants, and I don’t think supplemental CoQ10 makes it into the mitochondria which is the other place it’s needed. So I think if you optimize nutrition, the body will take care of CoQ10 on its own. If supplements really do alter CoQ10 levels in mitochondria, then they might serve an anti-aging purpose, but it is a very expensive supplement and I doubt it actually helps, except as a partial replacement for zinc or copper or vitamin A deficiencies, which I don’t think are present on PHD.

  43. Thank you Paul, I will stick to bone broth and feeding window.

  44. I much prefer the taste of my Aroy D coconut CREAM than using coconut oil to eat/cook. Since it is the cream and not the coconut milk, do you know much I need to take in a day to get your recommended levels of MCT? Or is coconut oil just better and I should suck it up?! Thank you

  45. Hi Paul,

    I recently learned that I have the dreaded ApoE 4/4. Following a PhD diet and supplement routine, my Trigs are 105 and LDL 126.
    Of greater concern is that for the past year I have been having lower back pain and other joint pains and injuries.
    I am going to get tested for heavy metal toxicity, since I also have one allele for hemachromatosis (Chris Kresser says even one allele can indicate difficulty in removing iron).
    My question for you is: what changes to the PhD supplement routine would you recommend? I do not take copper, as I’ve read that E4/4 have difficulty with excess copper, and I already eat 20-30g/day of 85% dark chocolate.
    Any advice would be very much appreciated!!!

    Thank you,

    Jordan

  46. Hi Paul,

    My 70 year old father has been diagnoses with Parkinson’s and related dementia. Possibly Lewy Bodies Dementia. Is there an specific recommendations to diet and supplementation you would suggest?

    Thank you,

    Raj

  47. “Are there any” not “is there an”

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