Supplements

This page lists our supplement recommendations with links to products at Amazon. By purchasing via links on this page, you support the blog at no cost to yourself. Thank you for supporting our work!

Supplemental Foods

We recommend eating these “supplemental foods” on a regular schedule:

  • 3 egg yolks daily, 5 yolks daily for women who are pregnant or planning to become pregnant (for choline, folate, vitamin A)
  • A bowl of soup made from bone, joint, tendon, foot, or hoof stock, 3 days per week (for calcium, phosphorus, and collagen)
  • Fermented vegetables such as kimchi, sauerkraut, or fermented mixed vegetables (for nucleotides, probiotic bacteria, and vitamins K2 and B12), and other vegetables such as tomato, avocado, potato, sweet potato, banana, green leafy vegetables, and seaweeds such as dulse, daily (for potassium)
  • ¼ lb beef or lamb liver, weekly (copper, vitamin A, folate, choline). If you like, substitute ¼ lb chicken, duck, or goose liver weekly plus 30 g 85% dark chocolate daily
  • fish, shellfish, eggs, and kidneys, weekly (for selenium)

Daily Supplements

These are supplements we recommend be taken daily:

  • Sunshine and vitamin D3 as needed to achieve serum 25OHD of 40 ng/ml.
  • Vitamin K2 100 mcg or more
  • Magnesium 200 mg
  • Iodine 225 mcg
  • Vitamin C 1 g
  • Pantothenic acid (vitamin B-5) 500 mg
Vitamin D3
  • Seek total dose from sun, food, and supplements of 4,000 IU/day
  • Adjust to 25OHD level of 40 ng/ml (whites/Asians), 30 ng/ml (blacks)
Vitamin K2
  • Recommended dose: 100 mcg MK-7
  • Pharmacological, possibly therapeutic doses: 1000 mcg to 5 mg MK-4
Magnesium
  • Use chelate (e.g. glycinate) or citrate
  • Daily dose 200 mg
Iodine
  • Recommended dose 225 mcg/day (one tablet)
  • Nori sheets have about 50 mcg each; 2-4 per day replaces supplements
  • Supplementation is to prevent lengthy iodine droughts
Vitamin C
  • Low dose: 500 mg – 1 g per day
  • Under stress or viral infections, more may be needed
  • Powder is least expensive way to get large doses
Vitamin B-5 (pantothenic acid or pantethine)
  • 500 mg per day; we suggest daily due to its extreme safety
  • Acne/skin blemishes or low energy/endurance are symptoms of deficiency

Weekly Supplements

These are supplements we recommend be taken once a week:

  • B vitamins:
    • 50 to 100 mg each of B1, B2, and B6
    • 5 mg biotin
    • 500 mcg B12
  • Zinc 50 to 100 mg
  • Boron 3 mg
B1 (thiamin)
  • 50-100 mg weekly
B2 (riboflavin)
  • 100 mg per week
B6
  • For those who don’t take a B-50 complex
  • We recommend 50 mg to 100 mg per week
Biotin
  • We recommend 5 mg once per week
B12
  • We recommend 500 mcg to 1 mg once per week
  • Sublingual methylcobalamin is preferred
Zinc
  • We recommend about 50 mg per week
  • Be sure to follow our copper recommendations as copper-zinc balance is crucial
Boron
  • The 3 mg dose can be taken one to three times per week

Prenatal Supplements

The most important prenatal supplements are:

  • Extra duck, goose, or pastured chicken liver.
  • Extra egg yolks.

The following supplements may also be helpful during pregnancy or in the months leading up to conception. Note: We do not recommend prenatal multivitamins.

Choline
  • Not necessary if you eat enough egg yolks and liver
  • But extremely important during pregnancy, and safe
Inositol plus Choline
  • Not necessary if you eat enough egg yolks and liver
  • If supplementing choline, good to mix in some inositol
Iron (optional)
  • About 30% of pregnant women develop iron deficiency anemia
  • Don’t guess, test; blood tests will indicate if you need iron supplements

Optional Supplements


These supplements may be helpful for a significant fraction of the population. Experiment to see if they help you:

  • Probiotics
  • Chromium, 200-400 mcg per week (not necessary if you cook in stainless steel pots) and (optional) vanadium, 25 mcg per week
  • Lithium 5 to 10 mg per week
  • Silicon 5 mg to 25 mg daily
  • FOR PEOPLE WHO DO NOT EAT LIVER: Copper 2 mg per day
  • FOR PEOPLE WHO DO NOT EAT LIVER: Vitamin A from cod liver oil, 50,000 IU/week
  • FOR PEOPLE WHO DO NOT EAT MAKE BONE STOCK OR DRINK MINERAL WATER: Calcium up to 400 mg/day
  • B-50 complex (as a substitute for individual B supplements if you prefer fewer pills
  • Molybdenum 150 mcg per week
  • Taurine 500 mg to 5000 mg per week (higher doses may be therapeutic for small intestinal or systemic infections)
  • Selenium 0 or 200 mcg per week depending on selenium content of food (if food is produced in dry, flat areas = high selenium, no supplements; rainy, well-drained areas = 200 mcg/wk)
Probiotics
  • Bifidobacterium spp can help with leanness and weight loss.
  • Lactobacillus spp can help with acid reflux, bloating, SIBO, prediabetes, high triglycerides
More Probiotics
  • Bifidobacterium spp can help with leanness and weight loss.
  • Lactobacillus spp can help with small intestinal issues
More Probiotics
  • VSL#3 is a good mix for inflammatory bowel diseases.
  • Prescript Assist includes soil-based organisms that are a little riskier and should be taken only occasionally, not continuously, for therapeutic reasons.
Chromium
  • If you don’t cook in stainless steel, we recommend 200 mcg chromium one to three times per week
  • Stainless steel pots may release 88 mcg chromium per day of use
  • Optional: vanadium 25 mcg one to two times per week
Lithium
  • Best is to take 1 mg per day; 5 mg once or twice per week is next best
  • Caution: too much lithium can exacerbate hypothyroidism and increase potassium excretion
Silicon
  • Up to 25 mg per day
  • Most people would benefit from more silicon
  • Seaweed is a good food source
Copper (Only If Liver Is Not Eaten)
  • Target of 2-3 mg/day can be met by eating 1/4 lb beef or lamb liver per week
  • Do not supplement copper if you eat liver
Vitamin A (Only If Liver Is Not Eaten)
  • Target of 50,000 IU/week with remaining A needs met from carotenoids (green leafy vegetables and orange plants like carrots)
  • Do not supplement vitamin A if you eat liver, unless for therapeutic reasons
Calcium (If No Mineral Water or Bone Stock)
  • PHD foods may fall short of calcium target by up to 400 mg/day
  • Standard PHD prescription is to make up the difference with bone stock and/or mineral water
  • These supplements also replace magnesium supplement; aim for 300-500 mg calcium and 150-250 mg magnesium per day
B-50 complex
  • An alternative to the other B vitamins for those who prefer to take fewer pills
  • Not recommended more than once per week due to folic acid and niacin content
Molybdenum
  • We recommend 150 mcg to 1 mg per week
Taurine
  • We recommend 500 to 1000 mg weekly for healthy persons
  • Supports production of bile salts
Vitamin E
  • Red palm oil is a good food source
  • If supplementing, take mixed tocopherols and tocotrienols

Therapeutic Supplements

These supplements are unnecessary for healthy people but may be helpful in various disease conditions.

N-acetylcysteine
  • Precursor to glutathione
  • Recommended dose is 500 mg
  • Can take more in cases of severe chronic infection
Glycine
  • Supports collagen production, bile conjugation, and glutathione production
  • Desirable if you don’t eat daily extracellular matrix (bones, joints, tendons, skin, hooves)
  • Up to 2 teaspoons (10 g) per day
Creatine
  • Supports muscle growth and preservation; especially valuable for the elderly
  • Up to 1 teaspoon (5 g) per day
Melatonin
  • An important sleep hormone, deficient in many brain diseases, has antimicrobial activity
  • Take 1 mg sublingually just before bedtime
  • For larger doses, combine 5 mg time-release with 1 mg sublingual
Detoxification Aids
  • These can help bind toxins and excrete them in feces, preventing them from being re-absorbed in the colon
  • Likely to be helpful for most people suffering from chronic infection or environmental mold.

Miscellaneous


These items may be helpful in implementing Perfect Health Diet and Lifestyle advice.

Pill boxes
  • Set out pills once per week, aids remembering to take them
Pill cutter
  • For cutting tablets to reduce the dose

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Leave a comment ?

4,434 Comments.

  1. Hey paul Ive been looking for multi’s trying to help you out ih your search and found this beauty.
    http://www.wellnessresources.com/products/daily_energy.php

  2. I like this one, personally (taking 2 or 3/day): http://www.iherb.com/Thorne-Research-Basic-Nutrients-V-180-Veggie-Caps/18123?at=0
    Seems to be among the few multis that don’t bother my stomach and that I can feel working. Shame about all that B3, though (not to mention the price). Maybe it would really be better to buy the individual vitamins and minerals separately, as I already do with some of them.

  3. Hello Paul, I´m taking your recommendations for supplementation right now. But researching some advise around the web about sunlight exposure I stumbled upon with this researcher linked to Wise Traditions that states D toxicity can occur both from sunlight or/and D supplementation ,even at low doses as 1000 IU . Here´s the link to excerpts from his work: http://www.sunlightandvitamind.com/samples.htm

    A bit hesitation about this issue after reading that website, I´d like to know your opinion about it.

    Thanks ,
    Christian

  4. Hi Christian,

    I don’t think you can have toxicity from 1,000 IU and sunshine, unless (a) you’re deficient in vitamins A and K2, or (b) you have some genetic mutation in D handling.

    I would just make sure my A status was good by eating liver and egg yolks, and supplement K2, and not worry.

    I personally try to get sunshine when possible, and supplement up to 2500 IU per day in the winter.

  5. Paul, my father experienced fairly significant heart disease by the time he was in middle age. As a result, he suggested that I see a cardiologist who took my blood to run a Berkeley Panel, which consists of a very detailed cholesterol profile. My numbers were approxiamtely something like this:

    Total Cholesterol 240
    LDL 150
    HDL 55
    Triglycerides 70
    LP(a) 170

    He recommended that I take crestor and niaspan. I understand that high levels of LP(a)(anything above 30) are believed to strongly increase heart disease risk, especially when LDL is also high.

    Do you have any suggestions or thoughts on my situation? I’m not a big fan of taking prescriptions unless there’s just no other choice but I have been taking Crestor, 10 mg, every other day, without any problems to speak of.

    Thanks,
    David

  6. Hi David,

    I wouldn’t take any drugs for that. Everything is normal except the Lp(a). The LDL range associated with good health is fairly broad, 80 to 160, so I wouldn’t consider the 150 number either abnormal or unhealthy.

    It’s hard to interpret the Lp(a) because its physiological function is not known. It’s probably an immune molecule. Your body may have upregulated it in response to some condition which may or may not be producing detectable symptoms.

    But there’s no reason to think that drug manipulations will make your health better. Presumably Lp(a) evolved for a reason and it is serving some function in your body.

    So the only interventions I would support would be ones that we have independent reason to believe will improve health. Dr Davis has a lot of experience with which interventions reduce Lp(a): from http://www.trackyourplaque.com/blog/2011/07/lipoproteins-zero.html, wheat elimination, fish oil, vitamin D, iodine, and thyroid normalization.

    Best, Paul

  7. Paul,

    Thanks once again for all of the time you devote to answering questions here.

    I have read your thoughts on niacinamide both in the book and on the blog but am hoping that you can elaborate in light of all of the conflicting information out there. Specifically, there seem to be two areas of confusion and disagreement:

    1. You explain how niacinamide can promote bacterial infections. But many health practitioners claim that niacinamide is eminently helpful for mood disorders and neurodegenerative conditions — a large percentage of which must be due, if you are correct about bacterial infections being a major hidden cause of disease, to stealth bacterial infections!

    2. You write that niacinamide interferes with glucose metabolism. But many practitioners use it specifically to improve glucose metabolism: CFS doctor Amy Myhill, for example, appears to use it as her primary intervention for blood sugar problems. The studies that I can turn up online are contradictory.

    I am interested in any elaboration you can give (particularly on point 2, as you have written more extensively on point 1).

    Thank you!

  8. Paul,

    I noticed the newest version of Pure Encapsulations Nutrient 950 contains folate (and not folic acid like my older bottle).

    http://www.pureencapsulations.com/itemdy00.asp?T1=MVF3

    And, Amazon now carries PE Nutrient 950 (and the various versions of it).

  9. Hi Paul and Shou-Ching,

    Hope you’re resting well for the Wise Traditions conference. I’ve been on a diligent search for a clean daily multivitamin and I think that taking a half dose (4 tablets) daily of Dr. Mercola’s Multivitamin plus whole food and vital minerals might be a good option. When you get a chance, take a look at the supplements facts(at the bottom of the page) http://products.mercola.com/multivitamin-vital-minerals/ and let me know. Thank you very much.

    God bless you,
    Joey

  10. Hi Paul,
    Are you a fan of macadamia nut oil for cooking, etc? I know the smoke point (varies a bit across sites) is higher (390) than butter (350) and olive oil (375) and the percentage of omega 6 is the same or lower (at least for the nut). I am assuming macadamia oil is preferred but don’t recall seeing it in your book or in the blog.
    Thank you,
    BG

  11. Hi Paul,

    Can I use potassium iodide tablets or should I take lugols solution containing both potassium iodide and iodine? Can the potassium iodide be converted to iodine by the body?

    Thanks,
    Tom

  12. Hi Joey,

    The whole-foods vitamins are a good idea, so that may be one to consider.

    By the way, Dr Mercola was at my talk at Wise Traditions and I’ll probably do a video interview with him soon.

    Hi BG,

    Macadamia oil is excellent for cooking. We don’t use it much because it’s not readily available in Boston, and expensive. I think all of the oils you mention are good.

    Hi Thomas,

    Potassium iodide is the salt and in water it dissolves into potassium and iodine, so you can take either one.

  13. i must admit, the iodine, iodide thing still confuses me as well. I may need to be a chemist to understand this one. I keep seeing references like the following;

    “Dr. [Guy] Abraham notes that research has shown that the thyroid gland prefers to utilize the iodide form of iodine, while other organs, such as the breast and ovaries, prefer the elemental form of iodine”

    Assuming this is true; & the thyroid gland prefers to utilize the iodide form.
    & if potassium iodide (K1) dissolves into potassium and iodine in water, can the body then convert some of that iodine back to iodide if it needs it (ie. for the thyroid)?

  14. Paul,

    Bump
    I am interested in any response to MM. Naturopaths advocate niacinamide for osteoarthritis at high doses.
    Please elaborate the efficacy.

  15. Hi MM, RichM,

    I don’t recall saying that niacinamide interferes with glucose metabolism; it supports it, that is why it promotes bacterial infections, since they metabolize glucose.

    Re niacinamide for osteoarthritis, there are limited studies: http://www.ncbi.nlm.nih.gov/pubmed?term=niacinamide%20osteoarthritis&itool=QuerySuggestion. In this paper, symptoms improved: http://www.ncbi.nlm.nih.gov/pubmed/8841834. Speculation about mechanisms here: http://www.ncbi.nlm.nih.gov/pubmed/10608273.

    Re mood disorders, the main effect of niacinamide seems to be to raise the levels of tryptophan in the brain, which gives temporary relief but sabotages immunity and is likely to backfire. See eg http://www.ncbi.nlm.nih.gov/pubmed/155389.

    Re neurodegenerative conditions, niacinamide can be neuroprotective; it is a major energy-supporting vitamin in neurons as it is in all glucose-metabolizing cells. See eg http://www.ncbi.nlm.nih.gov/pubmed/18381761, http://www.ncbi.nlm.nih.gov/pubmed/18260797. One has to make a judgment about what is causing the neuronal injury — is it bacterial or not? — to judge whether niacinamide will be beneficial.

  16. Hi Darrin,

    The iodide-iodine distinction is about the charge on the atom. Since electrons can be exchanged, these will be in some sort of equilibrium ratio in the blood. I wouldn’t expect the form of supplementation to make much difference.

  17. Those pesky electrons. Thx for the explanation Paul.
    Just found this; “IODINE, IODIDE What are the different forms of iodine” which was informative as well.
    http://bit.ly/dNjqJN

  18. Hi Paul,

    I see that you’re recommending NAC as a supplement. You’ve written several times about the importance of mucosal barriers, especially the gut mucosal barrier. Yet you’ve pointed out that NAC is mucolytic. Should people with leaky guts and gut issues worry about supplementing with NAC, as it might destroy the gut mucosal lining?

    Another thing I’m wondering about is the consumption of safe starches if you have gut dysbiosis. As I understand, starches can be hard to digest if your digestive system is not in good shape. That’s why both the GAPS diet and the SCD diet advice against its consumption until the digestion has improved. Now, I know the improtance of sufficient glucose intake for digestive health, but I wonder if when the consumed starch is not digested properly, could it not promote gut dysbiosis by sitting in the digestive tract fermenting, not being digested properly and cause more problems?

    Thank you,
    Eirik

  19. Here are articles which show that chromium isn’t an essential mineral:

    Chromium is not an essential trace element for mammals: effects of a “low-chromium diet.”
    http://dx.doi.org/?10.1007%2Fs00775-010-0734-y
    [Rats which were fed a chromium-free diet failed to show decreased glucose tolerance, or any side-effects, for many generation, therefore disproving chromium as an “essential nutrient.”]

    The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent.
    Vincent JB.
    [There had been at least two cases of chromium toxicity. Two people had liver and kidney damage due to chromium supplementation]

    Acute tubular necrosis associated with chromium picolinate-containing dietary supplement.
    Wani S, Weskamp C, Marple J, Spry L.

    Excessive chromium intake in children receiving total parenteral nutrition.
    http://www.ncbi.nlm.nih.gov/?pubmed/1346659
    [Children recieving total parenteral nutrition have kidney damage with chromium supplementation]

    Zinc and chromium in parenteral nutrition.
    K. N. Jeejeebhoy
    http://www.ncbi.nlm.nih.gov/pmc/?articles/PMC1911715/

    Clinical studies on chromium picolinate supplementation in diabetes mellitus–a review.
    http://www.ncbi.nlm.nih.gov/?pubmed/?17109600?dopt=Citation
    [This review suggests that the effects of chromium are inconsistent; people with diabetes benefit from chromium supplementation; but people without diabetes get no benefit. Thus, the effects of chromium supplementatation are pharmocological.]

    Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes
    http://care.diabetesjournals.org/content/29/8/1826.full
    [This is an example of how those with diabetes have increased insulin sensitivity when taking chromium.]

    Effects of chromium picolinate supplementation on body composition: a randomized, double-masked, placebo-controlled study
    http://linkinghub.elsevier.com/retrieve/pii/S0011393X96800804
    [This study is performed on overweight men, so they are likely to have insulin resistance. Chromium supplementation may have a compensatory effect, by lowering their insulin and advanced glycation end products. However, this does not suggest that chromium supplementation on healthy men would do the same.]

    Chromium picolinate supplementation in women: effects on body weight, composition, and iron status
    http://www.ncbi.nlm.nih.gov/?pubmed/1346659
    [This double-blind trial has shown no protective or insulin sensitising effects of chromium on women.]

    Only 1-2% of the chromium ingested is absorbed. Therefore, a person receiving 50 mcg of chromium from diet would absorb only 0.5-1 mcg of chromium.

    However, in studies on total parenteral nutrition, 100% of the chromium is absorbed, in contrast to the 1-2% from diet. Patents on total parenteral nutrition receive up to 200 mcg or 150 mcg of chromium. That is toxic, since chromium is directly injected into serum, thereby giving a dose hundreds of times than the typical dose you get from a diet. Smaller doses have no effect on blood sugar tolerance, in total parenteral nutrition. Therefore, it suggests that the effects of chromium are pharmacological.

    Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition
    http://www.ajcn.org/cgi/?pmidlookup?view=long&pmid=1?92066

    Chromium deficiency during total parenteral nutrition
    http://www.ncbi.nlm.nih.gov/pubmed/104057

    As the 1992 Lancet study had reported, children on total parental nutrition had kidney damage, and their tissues concentrations of chromium are hundreds of times greater than average. This is because only 1-2% of chromium is absorbed in the diet, but for those receiving total parental nutrition, 100% of the chromium is absorbed. This suggests that the effects of chromium are due to pharmacological doses, hundreds of times more than the typical dose from diet.

  20. Hi Paul,

    I’m 21 years old and I’ve had numerous health issues literally since I was an infant-when I was 8 weeks old I was diagnosed with GERD,I’ve suffered from depression and anxiety since my early teens, a year ago I had a parasitic round worm infection(and treated with albendazole), last January I passed kidney stones, I’ve had bouts of severe joint pain in my knees, both my shoulders “pop and grind” with certain everyday motions, I’ve had chronic ileocycal valve pain for over a year, I go through times of IBS, and I get cold hands and feet even at 65 degrees Fahrenheit.

    For the past few weeks I’ve been close to grain free and this significantly improved knee pain- in fact I don’t have knee pain anymore. In the past week, I’ve tried to closely follow the diet you recommend, and take a half dose of Mercola’s multivitamin, 1 g of vit. c, Life Extension’s Super K, 200 mcg Chromium picolinate, and 225 mcg of Norwegian kelp. In the past few days I’ve noticed an increase in anxiety, fatigue, constipation, forgetfulness, headaches, and loud gurgling sounds in my intestines- especially at night While I’m sleeping (and I stop eating usually 1-2 hours before going to bed).

    I know it’s a lot to consider, but any advice you have to offer I would greatly appreciate.

    Thank you and God bless,
    Joey

  21. Since we’ve got a bit of a multivitamin round-up going on, thought I’d throw mine into the mix in case it helps others. I like a lot of things about it (methyl B12, folate, less niacin, few fillers) but will still need to supplement magnesium and copper, since it doesn’t include those. And I wish it had a bit less chromium, but Linus Pauling Institute tells me 400mcg isn’t likely to be a problem.

    http://www.amazon.com/Designs-Health-Twice-vegetarian-capsules/dp/B002G3PRXY

  22. Can I take all the vitamins and minerals all at the same time?

    If yes great! If not what should the program be?

    Yes, they can be taken at the same time. It’s best to take them with food. Vitamin D is best taken earlier in the day, at breakfast or lunch. Splitting up the multivitamin from the others might have some slight benefit.

  23. Hi Paul. I was searching google for information on leaky gut and came across these pills. I wonder if they have any merit.

    http://www.vipdispensary.com/product/Essential_Therapeutics_Leaky_Gut_Formula_180/

    Thanks!

    Hi Steven,

    That’s not an approach I would favor. Glutamine can be utilized by pathogenic gut bacteria and can backfire. FOS is fiber and feeds pathogens as well as probiotic flora. N-acetyl D-glucosamine, I would favor natural foods – bone broth/gelatin and a modest amount of glucose-containing carbs. Acacia, I don’t know what that does.

  24. Hi Paul,

    can i get your quick opinion on these ‘old school’ supplements:

    – Bee products (i.e propolis, pollen, royal jelly)

    – Wheat / rice germ oil

    – High quality, low heat treated liver powder / tablets from grass-fed free-range cattle, such as the NOW Foods liver powder;

    – Brewers / nutritional yeast;

    Since cutting my meat intake back to only twice a week (most of the week my animal protein is eggs, raw cheese, wild fish and shellfish), I use Brewers Yeast on my ‘non-meat’ days to boost energy and well being.and it really helps

    Hi Rob,

    Bee products – good
    Wheat / rice germ oil – bad
    Liver powder – good but why not eat liver?
    Brewer’s yeast – not a fan, stimulates immune response, doubt that’s good generally; but if it helps you, I would stick with it.

    Best, Paul

  25. I see you recommend macadamia nut oil for cooking, but what about stir frying? I’ve heard you have to have a high smoking point for that. Many of my stir fry books rec peanut oil, which I know is a big NO. So I was thinking about ghee that has a higher smoke point than even peanut oil. I was going to try to do more stir fries cause they seem to be the perfect PHD meal served with a little white rice. 🙂 Thanks!

    Hi Mrs Smith,

    Macadamia nut oil is great … smoke point is determined not by the oil usually but by impurities in the oil, refined or pure macadamia oil would have a high smoke point, it is nut solids in the oil that smoke at lower temperature.

    Ghee is great! Use that.

    Best, Paul

  26. Hi Paul,
    i see from comments above that you tried (experimented with?) Horsetail.
    Out of interest, why or ‘for what’ did you give it a go?
    & did you replace it with something else (as the horsetail did not agree with you)?

    Hi Darrin,

    I just read that silicon could be beneficial and wanted to test it out. The first silicon supplement I tried contained horsetail. I didn’t have the same negative reaction to BioSil. On the other hand I didn’t notice any benefits either, which doesn’t mean there weren’t any.

    Best, Paul

  27. Which is worse;
    Retinyl Acetate or Retinyl Palmitate?

    What wikipedia says;
    “Retinyl Palmitate is a synthetic alternate for retinyl acetate in vitamin A supplements”

    “Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol”

  28. anyone have thoughts on primal defense vs the ultra formulation? i recall reading a post here that the ultra was not suggested, but its still listed here in suggested supplements.

    i’m trying to correct a rather severe case of dysbiosis after years of abxs. the regular formulation seems to be a helping a bit, but wonder if i would get better mileage with the ultra?

    thanks!

  29. Hi Paul (and possibly Mario too?),

    Some people (David Brownstein, for example) recommend supplementing both potassium iodide and inorganic iodine and say that potassium iodide alone isn’t very effective. What do you think of this kind of recommendation? Inorganic iodine isn’t very cheap.

  30. Hi Valtsu,

    I haven’t yet seen evidence to back up that claim. If you find any I would like to see it.

  31. Hey Paul,

    A couple of quick questions regarding mineral status:

    I have some form of hereditary hemochromatosis, which causes my iron levels to run consistently high regardless of what I eat. Restricting iron appears to slightly delay the inevitable increase in ferritin levels over time, but the effect is so minimal that I wonder whether I’m doing myself more harm than good by avoiding foods like grass-fed beef and liver.

    Would eating sensible amounts of liver be ill-advised for someone with this problem? Would the copper in the liver be properly absorbed, given that any iron also present will be absorbed to excess?

    In short, I’m curious to know how you would approach optimizing diet and supplementation in this situation to ensure that (a) iron levels remain under control and (b) copper and zinc intake is in the plateau range.

    I’m concerned that such high iron absorption might lead to chronic deficiency of copper or zinc or both.

    Thanks,
    Brendan

  32. I just ordered your book. I have hashimoto hyperthyroidism and I didn’t think I could take any iodine, as it causes a goiter. I have stopped eating wheat and sugar since August and I have gained 2 lbs. I hope your book helps with this weight gain . I also have rheumatoid arthritis and I got some vit K2 and it has helped with the pain. I look forward to reading your book!

  33. Hi Anne,

    Both RA and Hashimoto’s are probably caused by infections. I would try to fix diet and nutrition first, then experiment with antibiotics. You might try reading through our “arthritis” and “hypothyroidism” category posts for background.

    Also, the Road Back Foundation has some information on antibiotic treatments for RA.

    Please keep us posted on how things go!

    Best, Paul

  34. I’ve taken Melatonin for about 13 months to help me sleep when I was getting of Xanax. I have seen warnings about using it in the long term and taking it with antidepressants like ciprolax, which I recently started on. What I have not been able to find out is why this is or what effects it could have. I think I have a harder time focusing and worse short term memory (like taking instructions) but that could be worsening depression. I take up to 15mg to help me sleep usually only 10 with the last 5 taken if I have tossed and turned for more than an hour without falling sleep after which the 3rd pill will knock me out within minutes.

  35. paul,

    i’ve just ordered your book and it’s being shipped to my house.

    i have a few questions:

    1. i’m interested in the nature’s way Primadophilus Reuteri probiotic that you recommended, but i have a concern. please take a look at the second review for nature’s way garlicin, in which the author mentions that nature’s way puts toxic phthalates on all of their probiotics:

    http://www.amazon.com/gp/cdp/member-reviews/AE4Y2GX8YTZLD/ref=cm_cr_pr_auth_rev?ie=UTF8&sort_by=MostRecentReview

    i’ve pasted the excerpt here:
    “Worst of all, Nature’s Way puts this [phthalate] film on all of its probiotics, which sadly, I also used before discovering that it’s the same phthalates that are banned in Europe for use in children’s toys. Why would you want to eat plastic with your pills? ”

    what are your thoughts on this? would you still recommend the nature’s way Primadophilus Reuteri capsules?

    2. if you would not recommend nature’s way Primadophilus Reuteri capsules anymore, is there another reuteri probiotic supplement that you would recommend?

    3. i know that you naturally can get reuteri in breast milk, but is reuteri something that males would naturally have in their bodies when they become adults?

    4. why is reuteri so special?

    5. i’m curious why you recommended the centrum, as i’ve heard that tablets are not absorbed by the body. what are your thoughts on that?

    thanks

  36. Thanks, Fred. I wasn’t aware of the pthalates. Too bad.

    I’ll search for another source when I get a chance.

    Wikipedia has a good discussion of the benefits of reuteri: http://en.wikipedia.org/wiki/Lactobacillus_reuteri.

    I’m sure there are better multivitamins than Centrum, but I don’t believe that it is not absorbed.

  37. Regarding an alternate probiotic brand, Chris Kresser recommended Bio-Kult in the comments section of chriskresser.com/a-healthy-gut-is-the-hidden-key-to-weight-loss .

  38. i emailed nature’s way, and they said that they do not use phthalates in their enteric coating. hmmm, i’m not sure who to believe. but i guess i’ll believe nature’s way. this kind of annoys me, as i already bought the nature’s way reuteri powder with 3 billion cfu’s, as opposed to the capsules, which have 5 billion cfu’s.

    here’s what i emailed nature’s way:

    i have a few questions:

    1. do you use phthalates in the enteric coating in your probiotics?

    2. how much Lactobacillus reuteri (in terms of CFU’s) is in your Primadophilus Reuteri — 5 oz?

    3. how much Lactobacillus reuteri (in terms of CFU’s) is in your Primadophilus® Reuteri capsules?

    4. what specific strain(s) of reuteri are in the Primadophilus Reuteri — 5 oz?

    5. what specific strain(s) of reuteri are in the Primadophilus® Reuteri capsules?

    thanks

    here’s the response from nature’s way:

    Dear Fred:

    Thank you for contacting Nature’s Way, a Schwabe North America company. It is great to see that you are taking an interest in healthier living. I am happy to respond to your question on Primadophilus Reuteri. You would like to know the amounts of each strain of good bacteria in this formula and the specific strain of Reuteri that is used in our formulas.

    Nature’s Way is happy to provide information about how our nutritional supplements and natural medicines can work to support certain organs, systems, functions, and overall good health. The law prohibits us from diagnosing, treating, or making recommendations regarding the treatment of illness. In such cases, patients should consult a licensed health care professional who can work with them to determine appropriate medical treatment.

    Nature’s Ways Primadophilus Reuteri is a product that can be taken every day for over all good health. This product balances the natural good bacteria in the intestinal track helping with digestion and protecting the immune system. Nature’s Ways Primadophilus Reuteri is a proprietary blend so I am unable to provide the amount of CFUs for each strain. We do list the ingredients from most to least on the label. We also consider the specific Reuteri strain used in these formulas as proprietary information. This product is unique and we do not want other companies also offering this formula. The enteric coatings on our products are phthalate free.

    Thank you for taking the time to contact us. I am happy to answer any additional questions you may have on any of our great products. Please visit our website for information on Nature’s Ways full line of products. http://www.naturesway.com

    Best wishes for good health,

    Kristina Nelson
    Customer Service
    Schwabe North America
    Nature’s Way/Enzymatic Therapy
    1-800-962-8873
    http://www.naturesway.com

  39. Hi Fred,

    Thanks for emailing them! It’s good to hear they don’t use pthalates.

    Hi Rob,

    Most anti-depressants affect the serotonin-melatonin pathway and so there will be potential interactions with melatonin. Usually the drugs will raise melatonin levels.

    I would discuss possible interactions with your doctor.

  40. Regarding Fred’s question about possible side-effects from use of melatonin, I noticed a definite pronounced correlation between use of melatonin and symptoms of depression. The correlation was dramatic and occurred on several trials over a number of years. Depression appeared out of nowhere with use of melatonin and disappeared immediately on cessation. The problems began after I had used it for some time without problems. Since they persisted once they had begun, I just do not use melatonin at all any more. Mood is fine when I don’t take it.

  41. Callie: I wish it was that simple but depression runs in the family for me many generations back. I can’t say I noticed any change in it from before/after except maybe having dark circles under my eyes more often.

    Dr. P Jaminet: I would be curious to know more about the Serotonin-Melatonin pathways you mentioned. I’m a bit concerned now as I have already had my BP spike up to 140/81 (I’m 25 and fairly fit) just dys after taking Ciprolax the first time and getting a brush off fro the MD who prescribed me the meds at the walk in clinic.

  42. Callie, thanks, that’s an interesting data point.

    Rob, melatonin is made from serotonin. See http://www.endotext.org/neuroendo/neuroendo15/neuroendo15.htm.

    Re your side effects, Wikipedia (http://en.wikipedia.org/wiki/Melatonin) doesn’t mention those specific symptoms among known melatonin side effects, but it could disrupt circadian rhythms and that can have wide-ranging effects.

  43. Hi Paul, i’m sure your fed up with hearing about the controversies over the Centrum Multi by now, but i really do think that many of the ingredients they use (as in the forms of the nutrients themselves) are of serious concern – not because they are poorly absorbed, but because they are toxic. The Toxnet Toxicological Data Network clearly shows this.

    There used to be a website called http://www.centrumistoxic.com which has now been removed (probably because of libel claims), but the info on that site has been re-posted here: http://avalonhealthinfo.com/articles/centrum-is-toxic.html

    There are many decent low cost multi’s out there that use better forms of nutrients than Centrum – for example, the NOW Foods multi’s use decent ingredients and are cheap.

    Personally I use the Natures Own Euro Gold multi because it is ‘Food State’, which means the nutrients are not synthetically derived but instead are derived in natural states from live cultures / organisms

  44. hi paul, just wondering if red palm fruit oil has adequate amounts of vitamin k in it to warrant not getting a vitamin k supplement?

    also just wondering about metabolic rate and longevity – Nora Gedgaudas in Primal Mind/Primal Body believes a slow metabolism, which she equates to a car running on slow idle, is conducive to longevity while your book believes the body should “run hot”. is this too simplistic a comparison and is there research to support one over the other?

    thanks, james ardagna

  45. Thank you for your informative web site. Do you have any supplement recommendations for someone diagnosed with Parkinson disease who suffers from severe foot cramping?

  46. Hi Paul, your information is SO useful and direct. I made my first batch of fermented veggies tonight and can’t wait!

    Wondering about your opinion of the VitaCost Synergy Once Daily multi, which my nutritionist recommended:
    http://www.vitacost.com/Vitacost-Synergy-Once-Daily-Multi-Vitamin

    It seems to have a lot of the components you recommend in one capsule. I add my own magnesium, since it doesn’t contain any.

    If you have a moment to look, I’d appreciate knowing if there’s anything in there that you don’t like.

    Thanks so much, — Larry

    Hi Larry,

    It looks OK. As you say, you can get magnesium and calcium elsewhere. The two things I object to are the high dose of folic acid and the use of selenomethionine (other forms of selenium are better).

    Best, Paul

  47. I’m a Weston Pricer and a holistic nutrition coach and have been following a Paleo Diet so I really like your book. I do a combo of both programs — have the fermented foods & high fat diet but limit my grains as on a Paleo program & also because I have found that I’m grain intolerant. I can handle brown rice & quinoa pretty well.

    For my supplements I take a great brand of food based vitamins called Grown by Nature. Dr. Carolyn Dean, a MD & ND recommends them. I take fermented cod liver oil for my vitamin A & D.

    I do eat organic, raw honey as a sweetener but I also use stevia.

    You may want to suggest Miracle Noodles (www.miraclenoodle.com). They are made with konjac fiber and have only 3 grams of carbs and no calories. I also love Pure Wraps (purewaps.com) made only of coconut and use them to make sandwich out of.

    Thanks Suzanne. We had some of the coconut wraps at Wise Traditions, they were great, I was wondering who made them.

    Best, Paul

  48. Hi Paul, do you have any thoughts on this prenatal vitamin: http://www.drugstore.com/products/prod.asp?pid=326649 (SuperNutrition PreNatal Blend 2)? The B6 and folate numbers seem high to me, but I’m most concerned about the vitamin E and niacin (B3), based on what I read in your book.

    Since a dose is 6 pills, would it make sense to take a half dose per-day instead? That seems like a decent compromise to me, but considering the intended use (prenatal) I’m a bit paranoid.

    Hi Nathan,

    I think it’s very reasonable to be paranoid about the doses in that formulation. Calcium, vitamin E, niacin, folate, manganese, silica, and potentially vitamin A all could have a risk of excess. For instance, the UL for manganese is 11 mg/day (AI for pregnant women is 2.0 mg/day), and the recommended dose has 10 mg without any consideration of food or water intake, so it is really pressing the UL. I’m not familiar with risks for silica but the dose here is very high. The others are discussed in the book.

    I personally wouldn’t take 6 pills a day.

    Best, Paul

  49. Hi Paul,
    Just finished your book. Really enjoyed it. I had my gallbladder removed a year ago, and I believe I am having trouble digesting fats (although it certainly could be from all the toxic mess I’ve been eating). Do you know of any supplements to help digest fats? I would really like to get started eating as you suggest, but 65% fat is problematic due to the lack of a gallbladder. Thanks!

    Hi Dustin,

    Ox bile and other bile production supports are the most important. Take the bile along with the fatty meal. For example, Nutricology Ox Bile.

    Best, Paul

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